Dr. Joachim Schnier

Profil

Derzeitige StellungEmeritus
FachgebietAllgemeine Genetik und funktionelle Genomforschung
KeywordsCancer, Glioblastoma, ribosomes, Glycogen Metabolism, Cell cycle

Aktuelle Kontaktadresse

LandUSA
OrtDavis
Universität/InstitutionUniversity of California, Davis

Gastgeber*innen während der Förderung

Prof. Dr. Terrance LeightonDepartment of Microbiology and Immunology, University of California, Berkeley, Berkeley
Beginn der ersten Förderung01.08.1987

Programm(e)

1986Feodor Lynen-Forschungsstipendien-Programm

Publikationen (Auswahl)

2012DP Richman, K Nishi, SW Morell, JM Chang, MJ Ferns, RL Wollmann, RA Maselli, J Schnier, MA Agius : Acute severe animal model of anti-muscle-specific kinase myasthenia: combined postsynaptic and presynaptic changes. . In: Arch Neurol., 2012, 453-460
2012DP Richman, K Nishi, MJ Ferns, J Schnier, P Pytel, RA Maselli, MA Agius: Animal models of antimuscle-specific kinase myasthenia. . In: Ann N Y Acad Sci. , 2012, 140-147
2009K Nishi, H Inoue, JB Schnier, RH Rice: Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. . In: J Cell Biochem., 2009, 63-72
2008JB Schnier, K Nishi, WR Harley, FA Gorin: An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. . In: J Neurooncol. , 2008, 19-26
2008Joachim Schnier: Flash XML Applications. Elsevier, Focal Press, 2008
2007R Maselli, H Dris, J Schnier, J Cockrell, R Wollmann: Congenital myasthenic syndrome caused by two non-N88K rapsyn mutations. . In: Clin Genet. , 2007, 63-65
2005JB Schnier, K Nishi, PH Gumerlock, FA Gorin, EM Bradbury : Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. . In: BMC Urol. , 2005, 6
2004F Gorin, W Harley, J Schnier, B Lyeth, T Jue: Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. . In: Acta Neuropathol. , 2004, 235-244
2003JB Schnier, K Nishi, A Monks, FA Gorin, EM Bradbury: Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.. In: Biochem Biophys Res Commun., 2003, 126-134
2002K Nishi, JB Schnier, ME Bradbury: Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1. . In: Exp Cell Res., 2002, 233-243
2001A Kaiser, K Nishi, FA Gorin, DA Walsh, EM Bradbury, JB Schnier : The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. . In: Arch Biochem Biophys., 2001, 179-187
2000NG Oikonomakos, JB Schnier, SE Zographos, VT Skamnaki, KE Tsitsanou, LN Johnson: Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. . In: J Biol Chem. , 2000, 34566-34573
1999JB Schnier, G Kaur, A Kaiser, SF Stinson, EA Sausville, J Gardner, K Nishi, EM Bradbury, AM Senderowicz: Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein. . In: FEBS Lett., 1999, 100-104
1999PC Mack, DR Gandara, C Bowen, MJ Edelman, T Paglieroni, JB Schnier, EP Gelmann, PH Gumerlock: RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma. . In: Clin Cancer Res., 1999, 2596-2604
1998K Nishi, JB Schnier, EM Bradbury: The accumulation of cyclin-dependent kinase inhibitor p27kip1 is a primary response to staurosporine and independent of G1 cell cycle arrest. . In: Exp Cell Res., 1998, 222-231
1998SE Rought, PM Yau, JB Schnier, LF Chuang, RY Chuang: The effect of heptachlor, a chlorinated hydrocarbon insecticide, on p53 tumor suppressor in human lymphocytes.. In: Toxicol Lett., 1998, 29-36
1996JB Schnier, K Nishi, DW Goodrich, EM Bradbury : G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.. In: Proc Natl Acad Sci U S A. , 1996, 5941-5946
1994JB. Schnier, DM. Gadbois, K. Nishi, EM. Bradbury : The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells. . In: Cancer Res., 1994, 5959-5963
1992SY. Choi, BJ. Scherer, J. Schnier, MV. Davies, RJ. Kaufman, JW. Hershey: Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. . In: J Biol Chem. , 1992, 286-293
1991J. Schnier, HG. Schwelberger, Z. Smit-McBride, HA. Kang, JW. Hershey: Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.. In: Mol Cell Biol., 1991, 3105-3114
1990YJ. Bignon, JY. Shew, D. Rappolee, SL. Naylor, EY. Lee, J. Schnier, WH. Lee : A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.. In: Cell Growth Differ. , 1990, 647-651
1990J. Schnier, HS. Gewitz, SE. Behrens, A. Lee, C. Ginther, T. Leighton: Isolation and characterization of Bacillus stearothermophilus 30S and 50S ribosomal protein mutations.. In: J Bacteriol. , 1990, 7306-7309
1990J. Skouv, J. Schnier, MD. Rasmussen, AR. Subramanian, S. Pedersen: Ribosomal protein S1 of Escherichia coli is the effector for the regulation of its own synthesis. . In: J Biol Chem., 1990, 17044-17049
1990JW. Hershey, Z. Smit-McBride, J. Schnier: The role of mammalian initiation factor eIF-4D and its hypusine modification in translation. . In: Biochim Biophys Acta. , 1990, 160-162
1989P. Linder, PF. Lasko, M. Ashburner, P. Leroy, PJ. Nielsen, K. Nishi, J. Schnier, PP. Slonimski.: Birth of the D-E-A-D box. . In: Nature, 1989, 121-122
1989Z. Smit-McBride, J. Schnier, RJ. Kaufman, JW. Hershey: Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein. . In: J Biol Chem. , 1989, 18527-18530
1988K. Nishi, F. Morel-Deville, JW. Hershey, T. Leighton, J. Schnier: An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. . In: Nature, 1988, 496-498
1988J. Schnier, S. Thamm, R. Lurz, A. Hussain, G. Faist, B. Dobrinski.: Cloning and characterization of a gene from Rhizobium melilotii 2011 coding for ribosomal protein S1. . In: Nucleic Acids Res., 1988, 3075-3089
1988J. Schnier, K. Nishi Temperature-sensitive mutants with alterations in ribosomal protein L24 and isolation of intra- and extragenic suppressor mutants. . In: H.P. Noller, K. Moldave, Methods Enzymol. . 1988. 706-709
1988K. Nishi, J. Schnier: The phenotypic suppression of a mutation in the gene rplX for ribosomal protein L24 by mutations affecting the lon gene product for protease LA in Escherichia coli K12. . In: Mol Gen Genet., 1988, 177-181
1987K. Nishi K, M. Müller, J. Schnier: Spontaneous missense mutations in the rplX gene for ribosomal protein L24 from Escherichia coli. . In: J Bacteriol., 1987, 4854-4856
1987J. Schnier: The synthesis of heat-shock proteins after a decrease in translational capacity in Escherichia coli. . In: J Gen Microbiol., 1987, 3151-3158
1986K. Nishi, J. Schnier: A temperature-sensitive mutant in the gene rplX for ribosomal protein L24 and its suppression by spontaneous mutations in a 23S rRNA gene of Escherichia coli. . In: EMBO J., 1986, 1373-1376
1986J. Schnier, G. Stöffler, K. Nishi: Deletion and insertion mutants in the structural gene for ribosomal protein S1 from Escherichia coli. . In: J Biol Chem. , 1986, 11866-11871
1986J. Schnier, M. Kitakawa, K. Isono: The nucleotide sequence of an Escherichia coli chromosomal region containing the genes for ribosomal proteins S6, S18, L9 and an open reading frame.. In: Mol Gen Genet., 1986, 126-132
1985J. Schnier, G. Faist Comparative studies on the structural gene for the ribosomal protein S1 in ten bacterial species. . In: Mol Gen Genet., 1985, 476-481
1985K. Nishi, ER. Dabbs, J. Schnier: DNA sequence and complementation analysis of a mutation in the rplX gene from Escherichia coli leading to loss of ribosomal protein L24. . In: J Bacteriol., 1985, 890-894
1985J. Schnier, S. Isono, AG Cumberlidge, K. Isono: Unstable mutations caused by regional tandem multiplications in the gene for ribosomal protein S4 show thermosensitivity in Escherichia coli.. In: Mol Gen Genet. , 1985, 265-270
1984J. Schnier, K. Isono: Insertion of IS1 into the rpsE gene for ribosomal protein S5 causes cold-sensitivity in Escherichia coli. . In: Mol Gen Genet. , 1984, 364-366
1982J. Schnier, M. Kimura, K. Foulaki, AR Subramanian, K Isono, B. Wittmann-Liebold : Primary structure of Escherichia coli ribosomal protein S1 and of its gene rpsA.. In: Proc Natl Acad Sci U S A., 1982, 1008-1011
1982J. Schnier, K. Isono 1982 Mar 25;10(6):1857-65.: The DNA sequence of the gene rpsA of Escherichia coli coding for ribosomal protein S1.. In: Nucleic Acids Res. , 1982, 1857-1865
1980K. Isono, J. Schnier, M. Kitakawa : Genetic fine structure of the pyrE region containing the genes for ribosomal proteins L28 and L33 in Escherichia coli.. In: Mol Gen Genet., 1980, 311-317
1979J. Schnier, K. Isono: The gene for ribosomal protein L25 (rplY) maps at 47.3 min near nalA in Escherichia coli K-12.. In: Mol Gen Genet., 1979, 313-318
1977P. Fortnagel, J. Schnier: Ribosomal dimers produced by dimers of aurintricarboxylic acid.. In: FEBS Lett. , 1977, 288-292